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贵刊1986年第3期刊登缪诗霖等《水合氯醛水溶液有效期预测》一文,提示了水合氯醛水溶液的稳定情况,对配制与使用水合氯醛溶液者有一定参考价值。但笔者认为该文以恒温加速试验采用中国药典法测定水合氯醛含量,并不能准确地反映出水合氯醛的分解情况。文献介绍水合氯醛水溶液放置会分解生成盐酸与三氯醋酸等。生成的盐酸与三氯醋酸量与放置时问及温度有关。张万年指出,尽管水合氯醛的酸度测定前检查符合药典要求,但测定时因要多消耗碱量而使结果偏高约1.2%(标示量%)。在加温加速分解情
Your third issue in 1986 third issue published Miao Shilin et al “chloral hydrate solution is expected to be valid,” a paper that prompted the stability of aqueous chloral hydrate solution, the preparation and use of chloral hydrate solution has some reference value. However, I believe that this article to accelerate the accelerated test using Chinese Pharmacopoeia Determination of chloral hydrate content does not accurately reflect the decomposition of chloral hydrate. References Chloral hydrate aqueous solution placed will decompose into hydrochloric acid and trichloroacetic acid. The amount of hydrochloric acid and trichloroacetic acid generated when placed and asked about the temperature. Zhang Wannian pointed out that although the determination of the acidity of chloral hydrate pre-test in line with pharmacopoeia requirements, but the determination of excessive consumption of alkali and the result of the high level of about 1.2% (marked amount%). Speeding up decomposition in warm conditions