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通过血液学检查及应用羊抗大鼠纤维蛋白原抗体的荧光免疫组织化学方法，对实验组动物凝血系统改变及在组织中对纤维蛋白原抗原的表达进行探讨。结果发现：实验组动物血液中血小板数减少、纤维蛋白原浓度增高。荧光免疫组织化学观察可见在肺、肾、心、脑、肝及肿瘤组织血管内呈阳性反应。证明免疫荧光组织化学检查可明确显示血中高凝状态及早期血栓形成，这对于判断早期血栓形成及分析血栓变迁过程，具有重要临床意义。
Through hematology examination and application of goat anti-rat fibrinogen antibody by fluorescence immunohistochemistry, the change of coagulation system and the expression of fibrinogen antigen in the experimental group were discussed. The results showed that: Experimental animals, blood platelets decreased, fibrinogen concentration increased. Fluorescent immunohistochemical staining showed positive reaction in the blood vessels of lung, kidney, heart, brain, liver and tumor tissues. Immunofluorescence histochemical examination can clearly show the blood hypercoagulable state and early thrombosis, which has important clinical significance for judging the early thrombosis and analyzing the process of thrombus.