论文部分内容阅读
细粒棘球绦虫原头蚴在体外培养中与3种不同浓度的丙硫咪唑(10μg/ml,20μg/ml,40μg/ml)作用96小时后,原头蚴死亡率分别为48.5±3.2％、55.6±3.8％、66.4±4.2％。扫描电镜观察可见原头蚴多呈外翻型,顶突界面缺损,部分头钩脱落,吸盘变形,体表出现边缘不整齐的凹陷及皮层细胞脱落。丙硫咪唑治疗继发性小鼠包虫病(0.1g·kg·d×10,灌胃)的囊肿减轻率为72.2％,与对照组相比有显著性差异(P<0.05)。丙硫咪唑用于治疗10例细粒棘球蚴病患者(15mg·kg·d,连服14天为一疗程,每例4～12疗程),提示有较好的近期疗效,可能是一种有希望的抗包虫药物。
Echinococcus granulosus Echinococcus granulosus cultured in vitro with three different concentrations of albendazole (10μg / ml, 20μg / ml, 40μg / ml) after 96 hours, the protoscoleces mortality were 48.5 ± 3.2% , 55.6 ± 3.8%, 66.4 ± 4.2%. Scanning electron microscopy showed that the original cercariae were everted type, the top of the popliteal defect, part of the first hook off, the sucker deformation, surface irregular edge of the depression and cortical cells fall off. The reduction rate of cyst in albicans treated with albendazole was 72.2% (P <0.05), which was significantly higher than that of the control group (0.1g · kg · d × 10). Cetamidazole for the treatment of 10 cases of patients with Echinococcus granulosus (15mg · kg · d, and even served 14 days for a course of treatment, 4 cases for each course of 12), suggesting a better short-term efficacy may be a Hopeful anti-hydatid drugs.