抗癫痫药 (ＡＥＤ )在临床应用后不久 ,即有学者发现少数患者应用后发作次数反而增加 ,但一直未引起临床医生的重视[1] ,近 2 0年才有了明确的证据 (表 1) [2 ,3 ] 。表 1　5个安慰剂对照组研究中癫痫部分性发作频率变化 (% )组别例数发作频率减少 (% )5 0 2 5～ 5 0 2 5发作 Shortly after the clinical application of antiepileptic drugs (AEDs), some scholars have found that the number of seizures has increased after the application of a small number of patients, but it has not attracted the attention of clinicians [1] and there is definite evidence in the past 20 years (Table 1 ) [twenty three ] . Table 1 Episodes partial frequency of seizures in 5 placebo control studies (%) Group Number of cases Number of seizures decreased (%) 5 0 2 5 ~ 5 0 2 5 Attacks