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一叶萩碱（ＳＣＲＮ）为中草药一叶的主要生物碱。在体外细胞培养及动物实验证实ＳＣＲＮ具有明显的抗Ⅰ型单纯疱疹病毒（ＨＳＶ－１）活性的作用基础上，本文应用０．１％ＳＣＲＮ点眼剂及０．１％无环鸟苷点眼剂治疗临床单疱病毒角膜炎患者５８例（６７眼），进行疗效对比观察，同时对患者治疗前后泪液中ＳＩｇＡ及锌离子含量的变化进行了动态检测。结果表明ＳＣＲＮ点眼剂治疗ＨＳＫ患者具有显著的疗效，尤其在治疗浅层型ＨＳＫ及降低复发率方面更为突出。经过ＳＣＲＮ治疗的患者泪液中ＳＩｇＡ及锌离子水平显著提高，接近正常水平；作者阐明、分析了ＳＣＲＮ治疗ＨＳＫ的作用机制。
Monosodium citrate (SCRN) is the main alkaloid of a leaf of Chinese herbal medicine. In vitro cell culture and animal experiments confirmed that SCRN has a clear anti-herpes simplex virus type 1 (HSV-1) activity on the basis of this article the application of 0.1% SCRN eye drops and 0.1% acyclovir eye drops treatment Fifty-eight patients (67 eyes) with clinical herpes simplex virus keratitis were observed the curative effect and the changes of SIgA and zinc ion in tear fluid before and after treatment were detected dynamically. The results show that SCRN eye drops in the treatment of patients with HSK has a significant effect, especially in the treatment of superficial HSK and reduce the recurrence rate is more prominent. The levels of SIgA and zinc in tear were significantly higher in patients treated with SCRN, close to normal levels; the authors clarified and analyzed the mechanism of action of SCRN in the treatment of HSK.