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研究阿奇霉素与甲硝唑及奥美拉唑联合应用治疗幽门螺杆菌（ＨＰ）阳性的十二指肠溃疡。方法： ５３例符合条件的病人分成 ２组，其中 ２２例口服阿奇霉素 ２５０ｍｇ，每天 １次，共 ５天，甲硝唑４００ｍｇ，奥美拉唑 ２０ｍｇ，均每天 ２次，疗程 １周。另 １组口服阿奇霉素 ５００ｍｇ，每天 １次，共 ５天，甲硝唑 ４００ｍｇ，奥美拉唑 ２０ｍｇ，每天 ２次，疗程 １周。疗程结束后两组均继服奥美拉唑 ２０ｍｇ，每天 ２次，共 １周。疗程结束后 １月复查胃镜。结果：阿奇霉素 ５００ｍｇ组ＨＰ根除率 ９０．３２％与阿奇霉素２５０ｍｇ组ＨＰ根除率６８．１８％相比有显著性差异（Ｐ＜０．０５）。而两组溃疡愈合率分别为８７．１％和７２．７％，差异无显著性（Ｐ＞ ０．０５）。两组病人副反应总发生率为 １５．０９％，未发现严重副反应。结论：阿奇霉素与甲哨唑及奥美拉唑联合短程疗法有较理想的溃疡愈合率及ＨＰ根除率。阿奇霉素用量以每日 ５００ｍｇ为佳。
To study the combination of azithromycin with metronidazole and omeprazole in the treatment of Helicobacter pylori (HP) -positive duodenal ulcer. Methods: 53 eligible patients were divided into two groups. Among them, 22 patients received azithromycin 250 mg once daily for 5 days, metronidazole 400 mg and omeprazole 20 mg twice daily for 1 week. Another group of oral azithromycin 500mg, 1 day, a total of 5 days, metronidazole 400mg, omeprazole 20mg, 2 times a day for 1 week. After the end of the two groups were followed by omeprazole 20mg, 2 times a day for a total of 1 week. Gastroscopy was reviewed in January after the end of treatment. Results: The eradication rate of HP in azithromycin 500mg group was significantly lower than that in azithromycin 250mg group (68.18%) (P <0.05). The ulcer healing rates in both groups were 87.1% and 72.7%, respectively, with no significant difference (P> 0.05). The total incidence of side effects in both groups was 15.09%, and no serious side effects were found. Conclusion: Azithromycin and metoprolol and omeprazole combined with short-course therapy have better ulcer healing rate and HP eradication rate. Azithromycin 500mg daily dosage is better.