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对20例丙型病毒性肝炎患者用重组α-2b干扰素治疗,观察其近、远期疗效,发现干扰素对丙型病毒性肝炎有效。治疗3个月(一疗程)后,60%的患者丙型肝炎病毒(HCV)RNA转阴,88.9%的患者肝功能恢复正常,但停药后其中部分患者HCVRNA又出现阳性,肝功能出现反复。随访1~2a,发现肝功能稳定正常者占52.6%,HCVRNA持续阴转者占31.6%。用干扰素治疗的丙型肝炎患者,凡早出现临床症状者,预后佳;HCVRNA持续阴转者,不易复发,病情稳定。
In 20 cases of hepatitis C patients with recombinant interferon α-2b treatment, to observe the short-term and long-term efficacy and found that interferon on hepatitis C effective. After 3 months of treatment (one course of treatment), HCV RNA was negative in 60% of patients and normal liver function was restored in 88.9% of patients, but HCVRNA was positive in some of the patients after stopping treatment. Liver function Appear repeatedly. Follow-up 1 ~ 2a, found that stable and normal liver function accounted for 52.6%, HCVRNA persistent overcast accounted for 31.6%. Hepatitis C patients treated with interferon, who had early clinical symptoms, a good prognosis; HCVRNA persistent overcast, not easy to relapse, stable condition.