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目的:主要观察奈达铂(NDP)+氟尿嘧啶(5-Fu)方案及奈达铂(NDP)+氟尿嘧啶(5-Fu)+中药方案治疗中晚期食管癌的近期疗效和毒副作用。方法:追踪观察:观察48例患者分为AB两组。A组NF:NDP/5-Fu NDP 60~100mg/m2,静滴,第1~2天。5-Fu:500~750mg/m2,静滴,第1—5天。每21天为1周期,3~4周期为1疗程。B组NF联合中药方案:NF方案具体用法同A组,配合中药旋覆代赭汤随症加减。结果:以化疗后复查食管造影肿瘤缩小程度,作为评价标准,可评价疗效48例,A组治疗24例,有效率为58.3%(14/24);B组治疗24例,有效率为62%(15/24)。B组与A组相比,具有明显改善中医证候的作用;卡氏评分提示可提高化疗病人的生活质量。同时对化疗中的血色素降低有保护作用,对心肝肾无明显毒性。结论:NF方案与NF联合中药方案治疗食管癌疗效B组比A组好,联合中药能够提高生存质量,改善症状,一定程度的延长生存时间。消化道不良反应和骨髓抑制,B组较A组轻。
Objective: To observe the short-term curative effect and side effects of NDP + 5-Fu regimen and NDP + 5-Fu + Chinese herbal medicine regimen on advanced esophageal cancer. Methods: Follow-up observation: 48 cases were divided into AB two groups. Group A NF: NDP / 5-Fu NDP 60 ~ 100mg / m2, intravenous infusion, the first day to two days. 5-Fu: 500 ~ 750mg / m2, intravenous infusion, the first 1-5 days. Every 21 days for a period of 3 to 4 cycles for a course of treatment. B group NF combined traditional Chinese medicine program: NF program with the specific use of the same A group, with the Chinese medicine on behalf of the Xuan Fu octopus with the addition and subtraction. Results: The degree of tumor reduction after esophagectomy was evaluated. As the evaluation criteria, 48 cases could be evaluated. A group of 24 cases, the effective rate was 58.3% (14/24); B group of 24 cases, the effective rate was 62% (15/24). Compared with group A, group B has the effect of significantly improving TCM syndromes; and the cardiograph score can improve the quality of life of chemotherapy patients. At the same time to reduce the hemoglobin in chemotherapy has a protective effect, no significant toxicity on the heart, liver and kidney. Conclusion: NF and NF combined Chinese medicine treatment of esophageal cancer group B better than the A group, combined with traditional Chinese medicine can improve the quality of life, improve symptoms, to some extent extend the survival time. Gastrointestinal adverse reactions and bone marrow suppression, B group lighter than the A group.