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目的:分析CEA、CA153、AFP和CRP检测在鉴别胸腔积液中的价值。方法:以75例良性胸腔积液和25恶性胸腔积液患者为研究对象,使用电化学发光免疫法检测胸腔积液中CEA、CA153、AFP和CRP浓度水平。结果:恶性胸腔积液和良性胸腔积液的CEA、CA153、AFP和CRP浓度差异显著(P<0.05);AFP的灵敏度显著高于其它指标(P<0.05),CEA和CA153的特异度、阳性预测值显著高于AFP和CRP(P<0.05),准确度和阴性预测值差异不显著。结论:CEA、CA153、AFP和CRP在鉴别胸腔积液中均有一定价值,但不利于早期诊断疾病。
Objective: To analyze the value of CEA, CA153, AFP and CRP in the differential diagnosis of pleural effusion. Methods: Seventy - five patients with benign pleural effusion and 25 malignant pleural effusion were enrolled in this study. Concentrations of CEA, CA153, AFP and CRP in pleural effusion were detected by using chemiluminescence immunoassay. Results: The concentrations of CEA, CA153, AFP and CRP in malignant pleural effusion and benign pleural effusion were significantly different (P <0.05). The sensitivity of AFP was significantly higher than that of other indicators (P <0.05). The specificity and positive of CEA and CA153 The predictive value was significantly higher than AFP and CRP (P <0.05), the accuracy and negative predictive value was not significantly different. Conclusion: CEA, CA153, AFP and CRP have certain value in the differential diagnosis of pleural effusion, but not conducive to the early diagnosis of disease.