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目的研究血小板参数在慢性肝炎肝纤维化分期中的应用价值,探讨一种更简单的预测肝纤维化的指标。方法选取慢性病毒性肝炎患者210例,行肝组织病理学进行确诊和肝纤维化程度的分级,以全自动血球分析仪检测血小板平均计数、平均血小板体积、血小板分布宽度和血小板压积。结果随着肝纤维化的进展,血小板平均计数和血小板压积呈现下降趋势(r=-0.838、-0.781,P<0.01),特别是S4期,血小板平均计数明显降低;平均血小板体积与肝纤维化程度呈正相关关系(r=0.398,P<0.01)。结论动态监测血小板部分参数可作为判断肝纤维化进展的二级预防参考指标,在预示肝纤维化的进程上有一定的指导作用,值得临床的推广应用。
Objective To study the value of platelet parameters in the staging of liver fibrosis in chronic hepatitis and to explore a simpler index to predict liver fibrosis. Methods A total of 210 patients with chronic viral hepatitis were enrolled in the study. Liver histopathology was used to confirm the grade of liver fibrosis. The mean platelet count, average platelet volume, platelet distribution width and platelet pressure were measured by automatic hematology analyzer. Results With the progress of liver fibrosis, the average platelet count and platelet pressure showed a decreasing trend (r = -0.838, -0.781, P <0.01), especially in S4 phase. The average platelet count decreased significantly. The degree of chemical reaction was positively correlated (r = 0.398, P <0.01). Conclusion The dynamic monitoring of platelet parameters can be used as a secondary prevention reference to judge the progress of hepatic fibrosis, which can guide the progression of liver fibrosis and is worthy of popularization and application.