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目的：比较３个作用机理不同的舒血管药在不同激动剂所致预收缩血管中的作用特点。方法：以高Ｋ＋及去甲肾上腺素预收缩家兔主动脉条，观察维拉帕米、福司考林和克罗马卡林的舒血管特点。结果：维拉帕米对高Ｋ＋收缩的舒张明显大于其对去甲肾上腺素预收缩血管的舒张作用，相反福司考林和克罗马卡林对去甲肾上腺素收缩的舒张远较其对高Ｋ＋收缩的舒张作用为大。克罗马卡林对高Ｋ＋预收缩血管的舒张作用比福司考林微弱得多。结论：维拉帕米、福司考林、克罗马卡林的舒血管效应各有其不同特点。为研究未知扩血管药的作用原理提供参考。
OBJECTIVE: To compare the effects of three vasodilators with different mechanisms of action on pre-contracting blood vessels induced by different agonists. Methods: Rabbit aortic strips were pre-contracted with high K + and norepinephrine to observe the vasorelaxation characteristics of verapamil, forskolin and kr -macline. RESULTS: Verapamil had a significantly greater relaxation of high K + contraction than its effect on norepinephrine precontracted vasodilation. Contrary, Forskolin and Cromakalin showed significantly greater noradrenaline contractions than those of high K + Systolic relaxation is large. Krokalim’s effect on vasodilation of high K + pre-contracted blood vessels is much weaker than that of forskolin. Conclusions: The vasodilator effects of verapamil, forskolin, and crotamarine have different characteristics. It provides a reference for studying the action principle of unknown vasodilator.