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目的：为神经纤维对哺乳动物尤其是灵长类动物垂体前叶腺细胞的直接调节作用提供形态学证据．方法：用抗Ｓｙｎａｐｔｏｐｈｙｓｉｎ（ＳＹＮ）单克隆抗体，对ＭａｃａｃａＭｕｌａｔａ猴垂体前叶进行了免疫组化染色．结果：猴垂体前叶ＳＹＮ的免疫反应性主要有膨体型和纤维型两种形式．膨体型表现为大小不等、深染的点状结构．纤维型表现为细、短浅染的ＳＹＮ免疫反应神经纤维，其上分布着大小不等、深染的膨体．ＳＹＮ免疫反应膨体和纤维均分布在腺细胞之间，或沿着细胞团边界走行，与腺细胞密切接触．结论：猴垂体前叶ＳＹＮ免疫反应膨体反映了神经末梢中突触小泡的存在，为“哺乳动物垂体前叶神经体液双重调节的假说”提供了又一形态学依据
OBJECTIVE: To provide morphological evidence for the direct regulation of nerve fibers on the anterior pituitary gland cells of mammals, especially primates. METHODS: Immunohistochemical staining of the anterior pituitary of Macaca Mulata monkey was performed with anti-synaptophysin (SYN) monoclonal antibody. RESULTS: The immunoreactivity of SYN in the anterior pituitary of monkey was mainly in the form of bulky and fibrous forms. Bulky performance of the size range, deep-dyed dot-like structure. Fibers showed fine, short stained SYN immunoreactive nerve fibers, which are distributed on the size of the deep-stained bulge. SYN immune response bulge and fibers are distributed between the glandular cells, or along the cell mass border line, in close contact with glandular cells. Conclusion: The bulge of SYN immunoreactivity in the anterior pituitary gland of the monkey reflects the existence of synaptic vesicles in the nerve endings and provides a new morphological basis for the hypothesis that the mammalian pituitary neuro-humoral double-regulation