急性白血病发病机制之一为细胞分化障碍,致某阶段幼稚细胞大量聚积。治疗方法为应用小剂量药物促使白血病细胞成熟、分化,或大剂量细胞毒药物致骨髓抑制从而取得缓解。既往采用后一种治疗方案。1978年Sachs 指出,体外试验表明阿糖胞苷(Ara-C)有促进细胞分化作用。1979年 Baccarani等首先应用小剂量阿糖胞苷治疗急性白血 One of the pathogenesis of acute leukemia is cell differentiation disorder, resulting in a large accumulation of naive cells in a certain stage. Treatment for the application of small doses of drugs to promote leukemia cells mature, differentiated, or large doses of cytotoxic drugs induced bone marrow suppression and thus ease. Past use of the latter treatment. Sachs in 1978 pointed out that in vitro experiments showed that cytarabine (Ara-C) can promote cell differentiation. In 1979, Baccarani first applied low-dose cytarabine to treat acute leukemia