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目的:观察西宁地区新生儿窒息时心肌酶谱的变化,以探讨该酶测定的临床意义,为早期干预治疗提供依据。方法:用酶偶联测定法分别检测50例窒息新生儿及30例非窒息出生的新生儿作对照,于入院后24小时内采血进行血清心肌酶测定。结果:窒息越重,血清心肌酶越高,且在轻、重度窒息之间有显著性差别(P<0.05、P<0.01)。结论:在新生儿窒息后血清心肌酶谱发生明显改变,可作为临床判断病情轻重和预后的主要指标。
OBJECTIVE: To observe the changes of myocardial enzymes during neonatal asphyxia in Xining to explore the clinical significance of this enzyme assay, and to provide basis for early intervention. Methods: 50 cases of asphyxial newborns and 30 cases of non-asphyxiated newborn infants were detected by enzyme-linked immunosorbent assay (ELISA). Serum myocardial enzyme was measured within 24 hours after admission. Results: The heavier asphyxia, the higher serum myocardial enzymes, and there was a significant difference between mild and severe asphyxia (P <0.05, P <0.01). Conclusion: Serum myocardial enzymes change obviously after neonatal asphyxia, which can be used as the main index to judge the severity and prognosis of the patients.