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目的探究小儿心衰时血清β２－ＭＧ水平与心衰程度和地高辛血清浓度的关系。方法采用放射免疫技术对５６例心衰患儿测定血清β２－ＭＧ及２８例口服地高辛维持量的心衰患儿测定地高辛血浓度。结果心衰组血清β２－ＭＧ与对照组比较明显增高（Ｐ＜０．０１），且随着心衰程度加重而增加；在中度和重度心衰患者血清β２－ＭＧ水平较高（Ｐ＜０．０１或Ｐ＜０．００１），但在轻度心衰患者血清β２－ＭＧ未见改变（Ｐ＞０．０５）。血清β２－ＭＧ与地高辛血浓度存在显著正相关（ｒ＝０．７０８１，Ｐ＜０．０１）。结论测定心衰患儿血清β２－ＭＧ对判断病情及指导治疗心衰患儿具有一定意义。
Objective To explore the relationship between serum β2-MG level and the degree of heart failure and digoxin serum concentration in children with heart failure. Methods Fifty-six children with heart failure were tested for serum digoxin concentration by radioimmunoassay in children with heart failure who measured serum β2-MG and 28 patients with oral digoxin maintenance. Results Serum β2-MG in heart failure group was significantly higher than that in control group (P <0.01), and increased with the severity of heart failure. Serum β2-MG level was higher in patients with moderate and severe heart failure (P < 0.01 or P <0.001), but there was no change in serum β2-MG in patients with mild heart failure (P> 0.05). There was a significant positive correlation between serum β2-MG and digoxin blood concentration (r = 0.7081, P <0.01). Conclusion Determination of serum β2-MG in children with heart failure to determine the condition and guide the treatment of children with heart failure have a certain significance.