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芳醛、丙二腈和N-取代-4-哌啶酮在室温下,无溶剂、无催化剂反应,方便、快速地合成8-芳基-5,7,7-三氰基异喹啉衍生物.N-乙基-4-哌啶酮是首次应用于合成6-氨基-2-乙基-8-芳基-5,7,7(1H)-三氰基-2,3,8,8a-四氢异喹啉化合物.本方法具有反应条件温和、原料易得、操作简单、产率高、反应时间短,过程绿色等优点.产物的结构经过红外、核磁和高分辨质谱确定.本报道的方法是合成异喹啉类化合物的一条有效途径.
Aromatic aldehydes, malononitriles and N-substituted-4-piperidones are conveniently and rapidly synthesized in a solvent-free, catalyst-free manner at room temperature for the derivatization of 8-aryl-5,7,7-tricyanoisoquinoline N-ethyl-4-piperidone was first applied to the synthesis of 6-amino-2-ethyl-8-aryl-5,7,7 (1H) Tetrahydroisoquinoline compound has the advantages of mild reaction conditions, easy raw material obtaining, simple operation, high yield, short reaction time, process green, etc. The structure of the product is confirmed by infrared, nuclear magnetic resonance and high resolution mass spectrometry. The reported method is an effective way to synthesize isoquinolines.