不同性别BALB/c鼠对感染柯萨奇B组3型病毒(CVB_3)后所致心肌炎的敏感性具有显著差异。感染CVB_3后,雄性鼠比雌性鼠的心肌表现更严重的炎性细胞浸润,更高的病毒效价和更低的体液免疫应答。将感染CVB_3后7天的鼠脾CD_4~+T细胞体外培养14天发现,雄性鼠以产生γ干扰素(IFN-γ)及白细胞介素-2(IL-2)的CD_4~+细胞为主,而雌性鼠以产生IL-4及IL-5的CD_4~+细胞为主。通过对抗CVB_3IgG的分析发现,雄性鼠 The sensitivity of different gender BALB / c mice to myocarditis caused by Coxsackie B virus type 3 (CVB 3) was significantly different. Infected with CVB_3, male mice exhibited more severe inflammatory cell infiltration, higher viral titres, and lower humoral immune responses than the cardiac muscle of female mice. The murine splenic CD 4 ~ + T cells cultured in vitro for 7 days after CVB 3 infection for 14 days found that the male mice were predominantly CD 4 + cells producing IFN-γ and IL-2 , While female mice mainly produced CD_4 ~ + cells producing IL-4 and IL-5. By antagonizing the analysis of CVB_3IgG, male mice were found