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目的观察左氧氟沙星、阿莫西林、兰索拉唑三联疗法根除幽门螺杆菌(Hp)治疗的疗效及安全性。方法将90例14C-尿素呼气试验(14C-UBT)及快速尿素酶试验均阳性的胃、十二指肠溃疡及慢性胃炎患者随机分为2组各45例,治疗组用左氧氟沙星200mg,阿莫西林1000mg,兰索拉唑30mg;对照组用甲硝唑400mg,阿莫西林1000mg,兰索拉唑30mg。均为2次/d,疗程均为7d。结果疗程结束至少4周后复查14C-UBT,治疗组Hp根除率意向治疗分析(ITT)达82.22%和完成治疗分析(PP)达90.24%,对照组分别为64.44%和72.50%,治疗组Hp根除率明显高于对照组(P<0.05)。2组不良反应均较轻。结论左氧氟沙星、阿莫西林、兰索拉唑三联疗法Hp根除率高、安全性好,是一个较好的Hp根除方案。
Objective To observe the efficacy and safety of levofloxacin, amoxicillin and lansoprazole triple therapy in the treatment of Helicobacter pylori (Hp). Methods 90 cases of stomach, duodenal ulcer and chronic gastritis with positive 14C-urea breath test (14C-UBT) and rapid urease test were randomly divided into two groups of 45 cases each. The treatment group was given 200 mg levofloxacin Moxillin 1000mg, lansoprazole 30mg; control group with metronidazole 400mg, amoxicillin 1000mg, lansoprazole 30mg. Both 2 times / d, treatment were 7d. Results 14C-UBT was reviewed at least 4 weeks after the end of the course of treatment. The intention-to-treat (ITT) analysis of the Hp eradication rate was 82.22% in the treatment group and 90.24% in the completion of the treatment analysis (PP), 64.44% and 72.50% in the control group, Eradication rate was significantly higher than the control group (P <0.05). 2 adverse reactions were mild. Conclusion Levofloxacin, amoxicillin, lansoprazole triple therapy Hp eradication rate, good safety, is a good Hp eradication program.