本文报告一例不明原因的嗜酸性细胞明显持续增高的患者伴发严重的威胁生命的高血钙症,称为特发性嗜酸性细胞过多性综合征.伴高血钙者,文献尚未见报告,此是第一例。患者女性,55岁。因上腹不适、恶心、呕吐、体重锐减、咳痰、气短、双下肢无力而入院。8年前曾因左乳腺导管癌行根治术,当时无淋巴结及远处转移。体检:心尖搏动点左移至锁骨中线外2cm处,心尖闻及2级吹风样全收缩期杂音,伴室性奔马律,间断出现第四心音。肝脾明显增大。入院时白细胞49,000/mm~3,嗜酸细胞77%。血乳酸脱氢酶600mu/ml,血钙、磷、硷性磷酸酶、谷草转氨酶、尿素氮、补体第3,第4因子、IgE等均正常。抗核抗体稀释度1∶40,周围型。类风湿关节炎因子弱阳性。LE细胞,骨髓 This article reports an unexplained significant increase in eosinophils in patients with severe life-threatening hypercalcaemia, known as idiopathic eosinophilic syndrome. There is no report in the literature with hypercalcemia This is the first case. Patient female, 55 years old. Due to abdominal discomfort, nausea, vomiting, weight loss, expectoration, shortness of breath, weakness and lower extremity admission. 8 years ago due to radical mastectomy for left breast ductal carcinoma, there was no lymph node and distant metastasis. Physical examination: apical beating point left to 2cm outside the midline of the clavicle, apex smell and 2 grade hair-like systolic murmur, with room gallop, intermittent fourth heart sound. Liver and spleen increased significantly. Admission white blood cells 49,000 / mm ~ 3, 77% of eosinophils. Blood lactate dehydrogenase 600mu / ml, serum calcium, phosphorus, alkaline phosphatase, aspartate aminotransferase, urea nitrogen, complement 3, 4, IgE were normal. Anti-nuclear antibody dilution 1:40, peripheral type. Rheumatoid arthritis factor weakly positive. LE cells, bone marrow