Nano-Al2O3 particles modified AgCuNi filler was adopted to braze the SiO2 ceramic and TC4. The effects of filler size as well as the brazing temperature on the interfacial microstructure and mechanical property of the joints were investigated. Nanoscale filler reduced the phases dimen-sion and promoted the homogeneous distribution of microstructure, obtaining a higher joint strength when compared to microscale filler. The increase of brazing temperature made the accel-erating dissolution and diffusion of Ti, which promoted the increase of thickness of Ti4O7+TiSi2 layer adjacent to SiO2 ceramic and diffusion layer zone nearby TC4 alloy. The hypoeutectic struc-ture was produced in the brazing seam due to the high Ti content. The maximum shear strength of～40 MPa was obtained at 950 ℃for 10 min.