目的探讨强迫症与5－羟色胺(5－HT)的关系.方法该文选用氯丙咪嗪和氟西汀治疗38名强迫症病人,同时观察治疗前后患者血小板5－HT含量的变化.结果未服药强迫症病人血小板5－HT含量较正常人高(P＜0.01).经药物治疗后,患者的强迫症状明显好转、血小板5－HT含量逐渐下降,且治疗后血小板5－HT含量与Y－BOCS评分下降百分率呈负相关(R＝－0.6204,P＜0?01).结论提示强迫症发病可能与5－HT异常有关.“,”Objective The purpose of this study was to research the relationship between obsessive-compulsive disordor(OCD) and 5-hydroxtryptamine(5-HT). Methods 38 cases of OCD were treated with serotonin reuptake inhibitors,either climipramine or fluoxetine. Platelet 5-HT content of the patients were observed before and after treatment. Results It was found that the drug-free OCD patients had a higher level of platelet 5-HT content than that of the normal ( P