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目的研究国产阿仑膦酸钠治疗绝经后妇女骨质疏松症的经济学效果。方法选择120例绝经后妇女骨质疏松症患者,随机分为2组。治疗组60例,服用国产阿仑膦酸钠片(70 mg,qw)和碳酸钙D3钙片(1片,qd);对照组60例,服用进口阿仑膦酸钠片(70 mg,qw)和碳酸钙D3钙片(1片,qd)。治疗6个月后,观察2组的临床疗效和不良反应情况,并进行成本效果分析。结果治疗组、对照组治疗绝经后妇女骨质疏松症的总有效率分别为93.3%和95.0%(P>0.05),不良反应发生率分别为13.3%和11.7%(P>0.05),成本分别为1 227.98元和2 697.63元。结论阿仑膦酸钠国产制剂与进口制剂治疗绝经后妇女骨质疏松症疗效和不良反应均相当,但国产制剂成本低,值得临床推广使用。
Objective To study the economic effect of domestic alendronate on osteoporosis in postmenopausal women. Methods 120 cases of postmenopausal women with osteoporosis were randomly divided into two groups. 60 cases in the treatment group were treated with domestic alendronate sodium tablets (70 mg qw) and calcium carbonate D3 calcium tablets (qd), 60 cases in the control group were treated with imported alendronate sodium tablets (70 mg qw ) And calcium carbonate D3 calcium tablets (1, qd). After 6 months of treatment, the clinical efficacy and adverse reactions of the two groups were observed and the cost-effectiveness analysis was conducted. Results The total effective rates of the treatment group and the control group in the treatment of postmenopausal women with osteoporosis were 93.3% and 95.0% (P> 0.05), and the incidences of adverse reactions were 13.3% and 11.7% (P> 0.05) At 1 227.98 yuan and 2 697.63 yuan. Conclusion The efficacy and adverse reactions of domestic alendronate domestic preparation and imported preparation in the treatment of postmenopausal women with osteoporosis are quite similar, but the domestic preparation is low in cost and worthy of clinical promotion and use.