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１９９５年Ｍｅｕｎｉｅｒ［１］和Ｒｅｉｎｓｃｈｅｉｄ［２］等几乎同时从脑组织中分离出一种新的由１７个氨基酸组成的肽－称孤啡肽（ＯＦＱ）或痛敏肽，并证明孤啡肽特异性结合阿片受体样受体（ｏｐｉｏｉｄ－ｌｉｋｅｒｅｃｅｐｔｏｒ１ＯＬＲ１），为ＯＬＲ１的内源性配?
In 1995, Meunier [1] and Reinscheid [2] isolated a new 17 amino acid peptide called OFQ or nociceptin almost simultaneously from brain tissue and demonstrated that orphanin is specific Sex-binding opioid receptor-like receptor (opioid-like receptor1OLR1), OLR1 endogenous ligand?