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目的：了解地中海贫血高危妊娠胎儿宫内人巨细胞病毒（ＨＣＭＶ）感染状况。方法：应用聚合酶链反应技术（ＰＣＲ）对４７例地中海贫血高危妊娠胎儿产前绒毛组织、羊水细胞ＤＮＡ进行回顾性人巨细胞病毒ＤＮＡ（ＨＣＭＶ－ＤＮＡ）检测。结果：产前绒毛组织２９例，检出ＨＣＭＶ－ＤＮＡ２例，阳性率为６．９％；羊水细胞１８例，检出ＨＣＭＶ－ＤＮＡ１例，阳性率为５．６％。结论：地中海贫血高危妊娠胎儿与本地区的正常人群一样，产前绒毛、羊水中ＨＣＭＶ感染率较低。
Objective: To understand the status of human cytomegalovirus (HCMV) infection in fetuses with high risk of thalassemia. Methods: Retrospective human cytomegalovirus DNA (HCMV-DNA) was detected in DNA of 47 cases of fetuses with pre-natal chorionic villi and amniocytes from high-risk pregnancies of fetuses by polymerase chain reaction (PCR). Results: There were 29 cases of prenatal chorionic villus tissue, 2 cases of HCMV-DNA were detected, the positive rate was 6.9%; 18 cases of amniotic fluid cells, 1 case of HCMV-DNA was detected, the positive rate was 5.6%. CONCLUSIONS: The risk of HCMV infection in prenatal villi and amniotic fluid is lower in fetuses with high risk for thalassemia than in normal people in this region.