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为探讨凝血因子Ｖ基因Ｌｅｉｄｅｎ突变与孕妇严重先兆子痫的关系。方法：采用聚合酶链反应和限制性片段长度多态分析对３５例严重先兆子痫孕妇及９０例正常对照组孕妇进行等位基因检测。结果：３５例严重先兆子痫患者中有３人，为Ｌｅｉｄｅｎ突变杂合子（８．６％），而正常对照组中的９０人中只有１人为Ｌｅｉｄｅｎ突变杂合子（１．１％），二组间差异显著，ｘ２＝４．８９，Ｐ＜０．０５。结论：因子Ｖ基因Ｌｅｉｄｅｎ突变携带者患严重先兆子痫的风险高于正常组。
To investigate the relationship between Leiden mutation of coagulation factor V gene and severe pre-eclampsia in pregnant women. Methods: The alleles of 35 pregnant women with severe preeclampsia and 90 healthy controls were detected by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: Three of the 35 patients with severe preeclampsia were Leiden mutant heterozygotes (8.6%), whereas only 1 out of 90 patients in the normal control group were Leiden mutant heterozygotes (1.1%), Significant differences between groups, x2 = 4.89, P <0.05. CONCLUSIONS: The risk of developing severe preeclampsia in carriers of the Leiden mutation of V gene is higher than that of the normal controls.