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目的:探讨蛋白激酶B(PKB/Akt)在乙型肝炎病毒(HBV)感染原发性肝细胞癌组织中的表达及及临床价值。方法:采用SP免疫组化法,检测35例HBV感染原发性肝细胞癌(HBV肝癌)、乙肝后肝硬化和正常肝组织中PKB/Akt的表达。结果:HBV肝癌组和肝硬化组PKB阳性表达率分别为94.3%和66.7%,显著高于对照组(40.0%),有统计学差异(P<0.05);HBV肝癌组阳性表达率显著高于肝硬化组(P<0.05);肿瘤浸润和淋巴结转移组织中PKB/Akt阳性表达率显著高于无肿瘤浸润和淋巴结转移组织(P<0.05),PKB/Akt阳性表达率在性别、年龄、肿瘤大小和肿瘤分化程度等病理因素之间比较差异无统计学意义(P>0.05)。结论:PKB/Akt在HBV肝癌组织中呈高表达,PKB/Akt在HBV肝癌的肿瘤浸润、淋巴结转移的机制中起着重要的作用。
Objective: To investigate the expression of PKB / Akt in primary hepatocellular carcinoma (HCC) infected with Hepatitis B virus (HBV) and its clinical value. Methods: SP immunohistochemical method was used to detect the expression of PKB / Akt in 35 cases of HBV-infected primary hepatocellular carcinoma (HBV hepatocellular carcinoma), cirrhosis of liver cirrhosis and normal liver tissue. Results: The positive rates of PKB in hepatocellular carcinoma group and cirrhosis group were 94.3% and 66.7%, respectively, which were significantly higher than those in control group (40.0%, P <0.05) The positive rate of PKB / Akt expression in tumor infiltration and lymph node metastasis was significantly higher than that in non-tumor infiltration and lymph node metastasis (P <0.05). The positive rate of PKB / Akt in gender, age, tumor There was no significant difference in the size, tumor differentiation and other pathological factors (P> 0.05). Conclusion: PKB / Akt is highly expressed in hepatocellular carcinoma and PKB / Akt plays an important role in the mechanism of tumor invasion and lymph node metastasis in.