高血压肾损害是指由于高血压造成的肾脏结构损害和功能改变。血流动力学、血管活性物质及炎症因子等多种因素参与其中,醛固酮也起到了举足轻重的作用。醛固酮水钠潴留作用可致血容量增加,血压升高,醛固酮可通过此途径和独立于升高血压的机制产生肾脏损害。醛固酮的生成与醛固酮合酶基因多态性明显相关,因而醛固酮合酶基因多态性可影响肾损害的程度。本文分别综述了醛固酮及其合酶基因多态性与高血压肾损害的关系,探讨可能的相关性,为高血压 Hypertensive renal damage refers to renal structural damage and changes in function due to hypertension. Hemodynamics, vasoactive substances and inflammatory factors and other factors involved, aldosterone also played a decisive role. Aldosterone Shuinazhuliu effect can lead to increased blood volume, high blood pressure, aldosterone by this pathway and independent of the mechanism of raising blood pressure kidney damage. Aldosterone production and aldosterone synthase gene polymorphism was significantly related to aldosterone synthase gene polymorphisms can affect the extent of renal damage. This article reviews the relationship between aldosterone and its synthase gene polymorphisms and renal damage in hypertensive patients to explore the possible relevance of hypertension