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目的：从受体水平上为早期诊断和研究帕金森病（Ｐａｒｋｉｎｓｏｎｄｉｓｅａｓｅ，ＰＤ）提供依据。方法：对２只正常对照猴和１２只ＭＰＴＰ猴进行正电子发射计算机断层显像（ｐｏｓｉｔｒｏｎｅｍｉｓｉｏｎｔｏｍｏｇｒａｐｈｙ，ＰＥＴ）脑多巴胺受体显像，并在注药后不同时间测定血浆未代谢１８Ｆ多巴。结果：ＭＰＴＰ猴不论有无锥体外系症状或体征，ＰＥＴ受体影像纹状体放射性分布较对照组皆明显减淡或缺损，示踪剂在纹状体特异性结合时间放射性曲线呈明显减低。在各个时间点测得血浆未代谢１８Ｆ多巴皆高于对照组。结论：ＰＥＴ／１８Ｆ多巴胺受体显像和血浆１８Ｆ多巴放射性测定可用于临床型和亚临床型ＰＤ及其同类疾病的早期诊断和研究
OBJECTIVE: To provide a basis for the early diagnosis and study of Parkinson’s disease (PD) from the receptor level. Methods: Positron emission tomography (PET) brain dopamine receptor imaging was performed on two normal control monkeys and 12 MPTP monkeys. The 18F dopamine was not detected in plasma at different time after injection. Results: Whether or not there were extrapyramidal symptoms or signs in MPTP monkeys, the radioactivity distribution of the PET-labeled striatum was significantly reduced or absent compared with the control group, and the tracer showed a marked decrease in the time-radiation curve of striatum-specific binding . At each time point measured plasma 18F dopamine are not higher than the control group. Conclusion: PET / 18F dopamine receptor imaging and 18F dopamine radioactivity can be used in the early diagnosis and research of clinical and subclinical PD and their similar diseases