论文部分内容阅读
目的观察中胚层肾瘤的临床病理表现,探讨其诊断标准与鉴别诊断。方法 2例细胞型中胚层肾瘤均来自南宁市第一人民医院2012年4～6月儿外科手术切除标本。行HE染色及免疫组化染色观察镜下及免疫表型特点,并复习相关文献。结果 2例细胞型中胚层肾瘤患儿分别为生后26天和40天的女婴,均为单侧囊实性肿物,肿瘤切开均为局部囊性变。镜下肿瘤由束状排列的梭形细胞构成,细胞丰富,核分裂20～30个/10HPF,薄壁血管丰富,在肿瘤边缘均可见不成熟肾小球,其中1例还可见片状凝固性坏死。瘤细胞均vimentin(+),AFP强(+),Ki-67指数分别为20%和25%,其中1例SMA部分(+)。结论先天性中胚层肾瘤为具有独特组织病理学特点的肾良性或潜在恶性肿瘤,需要和其他肾良恶性肿瘤鉴别。
Objective To observe the clinicopathological features of mesoderm nephroma and discuss its diagnostic criteria and differential diagnosis. Methods 2 cases of cell mesoderm nephroma were from Nanning First People’s Hospital in 2012 April to June surgical resection of children specimens. Observed by HE staining and immunohistochemical staining and immunophenotype characteristics, and review the relevant literature. Results 2 cases of cell-type mesodermal neoplasia were 26 days and 40 days after birth, respectively, infants, all unilateral cystic tumor, tumor incision are localized cystic degeneration. Microscopic tumor consists of bundles of spindle-shaped cells, rich in cells, mitotic 20 ~ 30 / 10HPF, thin-walled vascular rich in the edge of the tumor can be seen immature glomeruli, of which 1 cases also visible flake coagulation necrosis . The tumor cells were vimentin (+), AFP strong (+), Ki-67 index were 20% and 25%, respectively, of which 1 SMA (+). Conclusions Congenital mesodermal nephroma is a neoplasm of benign or malignant neoplasms with unique histopathological features that need to be differentiated from other benign and malignant tumors.