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δ因子与重症慢性HBV感染有关。慢性HBV感染的猩猩经实验接种δ因子后肝损害加重,说明δ因子和HBV同时感染可导致某些乙型肝炎病例发展为暴发型肝炎。为确定暴发型乙型肝炎病例是否同时发生δ因子感染,作者对美国12名暴发型肝炎病例进行了研究。用RIA检测,此12例暴发型肝炎中,6例HBsAg和抗-HBc阳性(但抗-HBs均阴性),证明为暴发型乙型肝炎;另外6例表面为非乙型暴发型肝炎,由于在暴
δ factor and severe chronic HBV infection. Chronic HBV-infected chimpanzees exacerbated liver damage after inoculation with delta-factor, suggesting that simultaneous infection of delta-factor and HBV may lead to the development of some hepatitis B cases into fulminant hepatitis. To determine whether concurrent delta-factor infection occurs in fulminant hepatitis B patients, 12 cases of fulminant hepatitis in the United States were studied. Of the 12 cases of fulminant hepatitis, 6 were positive for HBsAg and anti-HBc (but all were negative for anti-HBs) by RIA, which was confirmed as fulminant hepatitis B. The other 6 were non-fulminant hepatitis B. In the storm