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自1986年以来伤寒病例增多,且有数起水源性暴发,大多为具有多重耐药性的噬菌体M_1型菌株引起。因此,对其临床有关问题似有重新认识的必要。一、耐药菌株的发现及分布自1950年以来,国外已从散发性伤寒病例中分离出对氯霉素和其他抗生素耐药的伤寒杆菌,之后国内外都有报告。一般而言,对氯霉素耐药者<5～10％。河南曾于1979年分离到25株伤寒杆菌,氯霉素的最低抑菌浓度高达170～230μg/ml。个别地区在流行期间曾有报道90％以上菌株耐药,如1986年
Since 1986 typhoid fever cases have increased, and there have been several water-borne outbreaks, mostly caused by multi-drug resistant bacteriophage M 1 strains. Therefore, it seems necessary to re-understand its clinical problems. First, the discovery and distribution of drug-resistant strains Since 1950, foreign countries have been isolated from typhoid fever cases of chloramphenicol and other antibiotic-resistant Salmonella typhi, both at home and abroad have been reported. In general, resistant to chloramphenicol <5 ~ 10%. In 1979, 25 strains of typhoid bacillus were isolated in Henan. The minimum inhibitory concentration of chloramphenicol was 170 ~ 230μg / ml. More than 90% of the strains were reported to be resistant in some areas during the epidemic, such as 1986