肾脏既是排泄器官,亦是具有内分泌功能的脏器。它不仅能产生、分泌激素,而且对某些激素的降解及其代谢产物的排出起着重要的作用。慢性肾功能衰竭时,上述功能减退,有多种血中激素浓度改变,靶组织对激素的反应性亦有变动。本文综述尿毒症时内分泌紊乱的发生机制, Kidney is both excretory organ, but also with endocrine function of the organ. It can not only produce and secrete hormones, but also play an important role in the degradation of certain hormones and the excretion of its metabolites. Chronic renal failure, the above-mentioned function decline, there are a variety of blood hormone levels change, the target tissue response to hormones also change. This article reviews the pathogenesis of endocrine disorders in uremia,