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氟哒拉平(Fludarabine,FDR)和2-氯脱氧腺苷(DCA)均对慢性淋巴细胞白血病(CLL)有效,虽两者作用机制相似,但仍有少数患者对FDR无效而对DCA确实有效。迄今尚不清楚对DCA有效的程度。本文报告28例对FDR治疗无效的CLL患者在持续输注DCA后的结果。患者中位年龄63岁(43～80),男21例,女7例。82％为晚期患者。从诊断到用DCA治疗的中位期为68月(6～139),在用FDR治疗前所有患者均用过烷化剂治疗。19例在用FDR
Both Fludarabine (FDR) and 2-chloro-deoxyadenosine (DCA) are effective in treating chronic lymphocytic leukemia (CLL). Although the mechanism of action of both is similar, a few patients still have no effect on FDR and are effective on DCA. To date, it is unclear how effective DCA is. This article reports the results of 28 patients with CLL refractory to FDR after continuous infusion of DCA. The median age was 63 years (43-80), 21 males and 7 females. 82% of patients with advanced. The median period from diagnosis to treatment with DCA was 68 months (range, 6 to 139) and all patients were treated with alkylating agents prior to treatment with FDR. 19 cases were using FDR