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目的:比较氟哌利多耳穴注射与氟哌利多肌肉注射对乳腺癌术后化疗恶心呕吐的疗效差异。方法:选择实施改良根治术的女性乳腺癌患者64例,随机分为观察组和对照组,每组32例。两组患者手术后均行E-T方案化疗,第1d给予表阿霉素静脉滴注,第3d给予紫杉醇静脉滴注。其中观察组于化疗期间行氟哌利多耳穴注射,选取耳穴胃、大肠、小肠、脾、皮质下、神门、贲门、枕分为两组穴位交替注射,每穴注射氟哌利多0.5mg,每日1次,共注射4次;对照组于化疗期间行氟哌利多2mg肌肉注射,每日1次,共注射4次。治疗4d后观察两组患者化疗期间恶心、呕吐的发生程度。结果:观察组患者化疗期间恶心发生率为46.9%(15/32),低于对照组的81.3%(26/32,P<0.01);观察组化疗期间呕吐发生率为28.1%(9/32),低于对照组的56.3%(18/32,P<0.01)。结论:氟哌利多耳穴注射预防乳腺癌术后化疗恶心呕吐疗效优于氟哌利多肌肉注射。
OBJECTIVE: To compare the efficacy of droperidol Auricular injection and droperidol intramuscular injection on postoperative chemotherapy and nausea and vomiting of breast cancer patients. Methods: Sixty-four patients with breast cancer who underwent modified radical mastectomy were randomly divided into observation group and control group, 32 cases in each group. Patients in both groups underwent E-T chemotherapy after the operation, intravenous epirubicin was given on the first day, and paclitaxel was given intravenously on the third day. The observation group was treated with droperidol Auricular injection during the chemotherapy period, and the acupoints of stomach, intestine, small intestine, spleen, cortex, divine door, cardia and occipital acupoints were randomly divided into two groups. The acupoints were injected alternately with 0.5 mg of droperidol Day 1, a total of 4 injections; control group during the chemotherapy droperidol 2mg intramuscularly, once daily, a total of 4 times. After 4 days of treatment, the incidence of nausea and vomiting during the chemotherapy in both groups was observed. Results: The incidence of nausea in the observation group was 46.9% (15/32) during chemotherapy, which was lower than 81.3% (26/32, P <0.01) in the control group. The incidence of vomiting in the observation group was 28.1% (9/32) ), Which was lower than 56.3% of the control group (18/32, P <0.01). Conclusion: The efficacy of droperidol Auricular Injection in preventing postoperative chemotherapy of nausea and vomiting of breast cancer is better than droperidol intramuscular injection.