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目的:探讨FAS、FASL与上皮性卵巢癌的关系。方法:采用免疫组化法检测10例正常卵巢组织、30例良性卵巢上皮肿瘤、32例交界性卵巢上皮性肿瘤和52例卵巢上皮癌组织中FAS、FASL的表达情况,分析两者在卵巢上皮性肿瘤发病机制中的作用。结果:卵巢上皮癌组织中FAS的表达明显低于交界性卵巢上皮肿瘤、良性卵巢上皮肿瘤和正常卵巢组织,差异有统计学意义,H=20.784,P<0.001;而正常卵巢组织、良性卵巢上皮肿瘤、交界性卵巢上皮肿瘤之间Fas表达差异无统计学意义,P>0.05。卵巢上皮癌组织中FASL的表达明显高于良性卵巢上皮肿瘤和正常卵巢组织,差异有统计学意义,P<0.05;而交界性卵巢上皮肿瘤、良性卵巢上皮肿瘤和正常卵巢组织之间的FASL表达差异无统计学意义,P>0.05。结论:FAS在卵巢上皮癌组织中表达下调;FASL在卵巢上皮癌组织中表达上调。FAS、FASL在卵巢上皮癌的发生发展过程中可能通过共同的机制参与卵巢上皮癌的发生。
Objective: To investigate the relationship between FAS, FASL and epithelial ovarian cancer. Methods: The expression of FAS and FASL in 10 cases of normal ovarian tissue, 30 cases of benign epithelial ovarian tumor, 32 cases of borderline ovarian epithelial tumor and 52 cases of epithelial ovarian cancer were detected by immunohistochemistry. The role of cancer in the pathogenesis. Results: The expression of FAS in ovarian epithelial carcinoma tissues was significantly lower than that in borderline ovarian epithelial tumors, benign ovarian epithelial tumors and normal ovarian tissues, with a significant difference (H = 20.784, P <0.001). However, normal ovarian tissues, There was no significant difference in Fas expression between tumor and borderline ovarian epithelial tumor (P> 0.05). The expression of FASL in epithelial ovarian cancer tissues was significantly higher than that in benign ovarian epithelial tumors and normal ovarian tissues, P <0.05; while the expression of FASL in borderline ovarian epithelial tumors, benign ovarian epithelial tumors and normal ovarian tissues The difference was not statistically significant, P> 0.05. Conclusion: The expression of FAS is down-regulated in epithelial ovarian cancer tissues. The expression of FASL is up-regulated in epithelial ovarian cancer tissues. FAS and FASL may participate in the occurrence of epithelial ovarian cancer through a common mechanism during the development and progression of epithelial ovarian cancer.