机体在遭受细菌或毒素损害时 ,炎症细胞被激活 ,细胞因子过量释放 ,产生持续的全身性炎症反应 ,介导广泛的组织损伤 ,导致感染性休克和多器官功能衰竭。细胞因子的基因多态性与机体受到刺激后细胞因子的分泌水平相关 ,与全身性感染的易感性、严重程度及预后相关。探明细胞因子基因多态性与全身性感染的关系 ,将为全身性感染的个体化免疫基因调控治疗奠定基础。 When the body is damaged by bacteria or toxins, inflammatory cells are activated and cytokines are released in excess, producing a sustained systemic inflammation that mediates extensive tissue damage resulting in septic shock and multiple organ failure. The genetic polymorphisms of cytokines are related to the secretion of cytokines after being stimulated by the body and are related to the susceptibility, severity and prognosis of systemic infection. To explore the relationship between cytokine gene polymorphism and systemic infection will lay the foundation for the regulation and treatment of individualized immune genes for systemic infection.