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目的观察比较替比夫定与阿德福韦酯治疗对慢性乙型肝炎患者肾脏功能的影响。方法选取医院进行治疗的慢性乙型肝炎患者84例作为研究对象,随机分为观察组和对照组,每组42例。对照组采用阿德福韦酯治疗,观察组采用替比夫定治疗,观察2组治疗前、治疗52周、治疗104周后患者的CR(血清肌酐)、e GFR(肾小球滤过率)指标变化情况。结果治疗前,2组CR、eGFR指标比较差异无统计学意义(P>0.05)。治疗52周后,观察组e GFR指标优于对照组(P<0.05)。治疗104周后,观察组CR、eGFR指标均优于对照组(P<0.05)。结论慢性乙型肝炎患者采用替比夫定治疗时可有效改善患者肾脏功能。
Objective To compare the effects of telbivudine and adefovir dipivoxil treatment on renal function in chronic hepatitis B patients. Methods Totally 84 patients with chronic hepatitis B who were treated in hospital were selected as study subjects and randomly divided into observation group and control group with 42 cases in each group. The control group was treated with adefovir dipivoxil, and the observation group was treated with telbivudine. The levels of CR (serum creatinine), e GFR (glomerular filtration rate) in the two groups before treatment and after 52 weeks of treatment were observed. Indicator changes. Results Before treatment, there was no significant difference in CR and eGFR between two groups (P> 0.05). After 52 weeks of treatment, eGFR in observation group was better than that in control group (P <0.05). After 104 weeks of treatment, CR and eGFR in observation group were better than those in control group (P <0.05). Conclusion Treatment of patients with chronic hepatitis B with telbivudine can effectively improve renal function in patients.