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目的:观察大剂量米非司酮联合氨甲蝶呤(MTX)保守治疗早期异位妊娠的疗效。方法:对29例输卵管妊娠给予米非司酮150 mg/d口服,3天1个疗程;并于服药第1天肌注氨甲蝶呤1 mg/kg或50 mg/m2,观察用药后生命体征、腹痛、阴道出血、血β-HCG下降情况及药物的毒副作用。结果:27例患者保守治疗成功,1例失败行剖腹患侧输卵管切除术,1例卵巢黄体破裂手术治疗。结论:大剂量米非司酮联合氨甲蝶呤(MTX)治疗输卵管妊娠安全有效,疗效显著,治愈率高,是保守治疗异位妊娠的一种重要方法。
Objective: To observe the efficacy of high-dose mifepristone combined with methotrexate (MTX) conservative treatment of early ectopic pregnancy. Methods: 29 cases of tubal pregnancy were given mifepristone 150 mg / d orally for 3 days for 1 course of treatment. On the first day of treatment, methotrexate was injected intramuscularly at a dose of 1 mg / kg or 50 mg / Signs, abdominal pain, vaginal bleeding, blood β-HCG decline and drug side effects. Results: Twenty-seven patients were successfully treated conservatively. One patient underwent cesarean section with cesarean section and one patient underwent ovarian luteal rupture. Conclusion: High dose of mifepristone combined with methotrexate (MTX) in the treatment of tubal pregnancy is safe and effective, with significant curative effect and high cure rate. It is an important method for the conservative treatment of ectopic pregnancy.