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目的探讨小剂量多巴胺在治疗新生儿窒息后肾损害的临床疗效。方法 67例窒息后肾损害新生儿,随机分为观察组(34例)和对照组(33例)。观察组以常规综合治疗为基础同时采取小剂量多巴胺治疗,对照组仅采取常规综合治疗。对比两组新生儿治疗效果以及肾功能改善情况。结果观察组治疗总有效率为94.12%,治疗后的肌酐和尿素氮分别为(66.1±14.5)μmol/L和(5.2±1.1)mmol/L;对照组治疗总有效率为81.82%,治疗后的肌酐和尿素氮分别为(87.9±18.7)μmol/L和(8.3±2.7)mmol/L;两组患儿治疗总有效率、肌酐以及尿素氮水平比较差异均有统计学意义(P<0.05)。结论小剂量多巴胺在治疗新生儿窒息后肾损害的临床疗效确切,有助于改善患儿肾功能,值得在临床上推广使用。
Objective To investigate the clinical efficacy of low-dose dopamine in the treatment of nephropathy after neonatal asphyxia. Methods Sixty-seven newborns with renal damage after asphyxia were randomly divided into observation group (34 cases) and control group (33 cases). The observation group was treated with low-dose dopamine at the same time on the basis of conventional comprehensive treatment, while the control group only took conventional comprehensive treatment. Comparison of two groups of neonatal treatment and improvement of renal function. Results The total effective rate in the observation group was 94.12%. The creatinine and urea nitrogen in the observation group were (66.1 ± 14.5) μmol / L and (5.2 ± 1.1) mmol / L, respectively. The total effective rate in the control group was 81.82% Creatinine and urea nitrogen were (87.9 ± 18.7) μmol / L and (8.3 ± 2.7) mmol / L, respectively. There was significant difference in total effective rate, creatinine and urea nitrogen between the two groups (P0.05 ). Conclusion The clinical efficacy of low-dose dopamine in treating renal damage after neonatal asphyxia is definite and helps to improve renal function in children. It is worth to be popularized in clinic.