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心血管疾病是目前全世界范围内致死和致残的主要疾病,其主要病理改变是动脉粥样硬化。越来越多的证据表明病理状态下活性氧簇生成增多所导致的血管功能异常在动脉粥样硬化的发生、发展过程起到了重要作用。解耦联蛋白2是位于线粒体内膜上的质子载体蛋白,通过解耦联作用能降低线粒体内膜电势,使活性氧簇产生减少,因而具有预防动脉粥样硬化的作用。
Cardiovascular disease is currently the leading cause of death and disability worldwide, and its major pathological change is atherosclerosis. There is a growing body of evidence that vascular dysfunction caused by increased production of reactive oxygen species in pathological states plays an important role in the development and progression of atherosclerosis. The uncoupling protein 2 is a proton carrier protein located in the mitochondrial inner membrane, which can reduce the potential of the mitochondrial inner membrane and reduce the production of reactive oxygen species through decoupling, thus having the effect of preventing atherosclerosis.