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为了提高新型近β钛合金Ti-3Zr-2Sn-3Mo-25Nb(TLM)的抗凝血性能,先通过优化溶胶凝胶技术在TLM合金试样表面制备出一层致密、均匀的TiO2薄膜,再结合表面官能化处理和静电层自组装技术,在TiO2薄膜表面构建一个多层肝素功能涂层。通过XRD分析改性处理后TLM合金表面涂层的相组成,借助SEM、AFM研究功能涂层的表面形貌和微观特征,通过动态凝血时间、溶血率、血小板粘附实验对TLM合金表面改性前后的抗凝血性能和血液相容性进行评估。结果表明,经表面肝素化修饰处理后,TLM合金试样表面光滑、平整,同时材料表面的动态凝血时间延长,溶血率明显降低,试样表面粘附的血小板很少且没有被明显激活,TLM合金的抗凝血性能和血液相容性均得到了明显的改善。
In order to improve the anticoagulant properties of a new type of near-Ti titanium alloy Ti-3Zr-2Sn-3Mo-25Nb (TLM), a dense and uniform TiO2 thin film was first prepared on the surface of the TLM alloy by the optimized sol-gel technique Combined with surface functionalization and electrostatic layer self-assembly technology, a multi-layer heparin functional coating is formed on the surface of TiO2 film. The phase composition of the surface coating of the TLM alloy after modification was analyzed by XRD. The surface morphology and microscopic features of the functional coating were studied by SEM and AFM. The surface properties of TLM alloy were modified by dynamic coagulation time, hemolysis rate and platelet adhesion test The anticoagulant properties and hemocompatibility were evaluated before and after. The results showed that the surface of TLM alloy was smooth and flat after surface heparinization treatment, meanwhile, the dynamic coagulation time on the surface of the material was prolonged and the hemolysis rate was obviously decreased. There was little and no obvious activation of TLM The anticoagulant properties and hemocompatibility of the alloy have been significantly improved.