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收集急、慢性肝炎、肝硬化、肝细胞癌及ＨＢＶ携带者血清４７２例，经聚合酶链反应（ＰＣＲ）分别检测血清中ＨＢＶＤＮＡ和ＨＣＶＲＮＡ片断，结果发现，ＨＢＶ－ＨＣＶ重叠感染５６例，重叠感染率为１１．９％，其中５０例（８９．３％）发展为慢性肝病，较单纯ＨＣＶ感染者（１５／３９，３８．５％）明显增高（Ｐ＜００１），提示ＨＢＶ－ＨＣＶ重叠感染可能加重了肝脏的慢性损伤。值得注意的是，５６例重叠感染者中，肝细胞癌的比率达３５．７％，高于ＨＢＶ或ＨＣＶ单一病毒感染者（Ｐ＜０．０５），提示ＨＢＶ和ＨＣＶ可能有协同致癌作用
472 cases of acute and chronic hepatitis, cirrhosis, hepatocellular carcinoma and serum of HBV carriers were collected. Serum HBVDNA and HCVRNA were detected by polymerase chain reaction (PCR). The results showed that 56 cases of HBV-HCV overlap infection and superinfection (11.9%), of which 50 (89.3%) developed chronic liver disease, compared with HCV infection alone (15/39, 38.5%) was significantly higher (P <0 01), suggesting that HBV-HCV Over-infection may exacerbate chronic damage to the liver. It is worth noting that the ratio of hepatocellular carcinoma in 35 patients with overlap was 35.7%, higher than those infected with HBV or HCV (P <0.05), suggesting that HBV and HCV may have a synergistic carcinogenic effect