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目的 研究苏州地区汉族人血小板糖蛋白Ⅲa基因TaqⅠ多态性与脑梗死发生的相关性。 方法 应用PCR技术结合TaqⅠ酶切分析、聚丙烯酰胺凝胶电泳 ,研究了苏州地区汉族正常人与脑梗死患者血小板糖蛋白Ⅲa基因TaqⅠ多态性特点。 结果 正常对照组TaqⅠ等位基因的频率分别为C 5 3.8%、A 4 6 .2 %。脑梗死组TaqⅠ等位基因频率分别为C 5 0 .6 %、A 4 9.4 %。脑梗死组和对照组之间无显著性差异 (P >0 .0 5 )。结论 苏州地区汉族人血小板糖蛋白Ⅲa基因TaqⅠ多态性与脑梗死发生无关。
Objective To investigate the association between TaqⅠ polymorphism of platelet glycoprotein Ⅲ a gene and the occurrence of cerebral infarction in Han nationality in Suzhou area. Methods The Taq Ⅰ polymorphism of platelet glycoprotein Ⅲ a gene in normal and cerebral infarction patients in Suzhou district of Suzhou was studied by PCR and Taq Ⅰ restriction enzyme digestion and polyacrylamide gel electrophoresis. Results The frequencies of the Taq I alleles in the normal control group were C 5 3.8% and A 46.2%, respectively. The frequencies of Taq I alleles in cerebral infarction group were C 50.6% and A 4 9.4% respectively. There was no significant difference between cerebral infarction group and control group (P> 0.05). Conclusion The Taq Ⅰ polymorphisms of platelet glycoprotein Ⅲ a gene in Suzhou Han population have nothing to do with the occurrence of cerebral infarction.