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目的评价浙江省儿童基因工程乙型病毒性肝炎(乙肝)疫苗基础免疫后5～11年抗体阴性者不同乙肝疫苗、不同针次加强免疫效果。方法 2009年9月在浙江省台州市、丽水市、衢州市选择1周岁内完成全程接种乙肝疫苗的5岁以上儿童4407例,采集静脉血,使用化学发光法检测血清乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)、乙肝病毒核心抗体(抗-HBc),选择免前三项指标全阴者2164例,按0、1、6完成3针乙肝疫苗接种。第1、3针乙肝疫苗接种后间隔1个月采血,免后检测抗-HBs。结果通过对接种第1、3剂次乙肝疫苗后1个月检测抗-HBs,其抗体阳转率大于95%以上,不同疫苗接种3剂次与接种1剂次免疫效果差异有统计学意义。结论乙肝疫苗免疫策略实施以来,疫苗免疫效果良好,但抗-HBs阳性率存在随时间推移逐步下降的趋势,建议对5岁以上免疫儿童实施加强免疫会有较好的效果。
Objective To evaluate the effects of different hepatitis B vaccines and different doses of hepatitis B vaccine on immunogenicity of hepatitis B virus (HBV) vaccine in Zhejiang Province from 5 to 11 years after the basic immunization. Methods A total of 4,407 children over the age of 5 were enrolled in September 2009 in Taizhou City, Lishui City and Quzhou City, Zhejiang Province. Within one year of their choice, 4,007 children over the age of 5 years were enrolled in this study. Venous blood was collected for detection of serum hepatitis B virus surface antigen (HBsAg) , Hepatitis B virus surface antibody (anti-HBs) and hepatitis B virus core antibody (anti-HBc). 2164 infants who chose the first three indicators of free radical were vaccinated with 3 doses of hepatitis B vaccine according to 0,1,6. The first and third doses of hepatitis B vaccination one month after vaccination, anti-HBs test. Results The anti-HBs antibody was detected more than 95% at 1 month after inoculation of the first and the third dose of Hepatitis B vaccine. There was significant difference in immunization effect between different vaccination doses and inoculation dose. Conclusion Since the implementation of the hepatitis B vaccine immunization strategy, the vaccine has a good immunization effect. However, the positive rate of anti-HBs tends to decrease gradually with the passage of time. It is suggested that immunization with immunized children over 5 years old will have a good effect.