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[目的]观察并对比不同类型的抗消化性溃疡(PU)的药物用于儿科临床的疗效。[方法]选取2008～2010年间儿科就诊的幽门螺杆菌(HP)检测呈阳性的PU患儿188例,通过计算机将其随机分为2组,各94例。A组除了采取临床常用口服西药外,另加服我院特制的中药合剂;B组仅服用A组的西药;2组均连续用药4周。观察A、B组患儿的溃疡愈合及HP根除率的比例,HP完全根除与未完全根除患儿之间的溃疡愈合比例。治疗结束后进行为期1年的随访,观察2组患者溃疡复发率。[结果]通过4周的治疗,A组患儿的溃疡愈合率及HP根除率均高于B组(P<0.05),2组中HP完全根除的患儿溃疡愈合率高于HP未完全根除的患儿,在1年的随访中A组溃疡复发率低于B组(P<0.05)。[结论]中西医结合治疗儿科PU的效果更好,值得临床推广。
[Objective] To observe and compare the different types of anti-peptic ulcer drugs for pediatric clinical efficacy. [Method] A total of 188 children with PU positive for Helicobacter pylori (HP) test were selected from 2008 to 2010. Pediatric patients were randomly divided into two groups (n = 94). In addition to the clinical use of oral medicine in western medicine group A, in addition to our hospital specially made of traditional Chinese medicine mixture; B group only taking A group of Western medicine; 2 groups were continuous medication for 4 weeks. The percentage of ulcer healing and HP eradication rate in children in group A and B was observed, and the percentage of ulcer healing between children with complete eradication and incomplete eradication was observed. After the treatment, a one-year follow-up was conducted to observe the ulcer recurrence rate in the two groups. [Result] After 4 weeks of treatment, the ulcer healing rate and HP eradication rate in children in group A were significantly higher than those in group B (P <0.05). The healing rate of ulcer in children with complete eradication in two groups was higher than that of HP incomplete eradication Of children, the recurrence rate of ulcer in group A was lower than that in group B at one year follow-up (P <0.05). [Conclusion] Integrative Chinese and Western medicine treatment of pediatric PU better, it is worth clinical promotion.