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目的分析2009-2014年深圳市福田区疑似预防接种异常反应(AEFI)的发生特征,评价疫苗安全性、预防接种服务质量和AEFI监测系统运转情况。方法通过中国“疑似预防接种异常反应信息管理系统”收集2009-2014年报告的个案数据,采用描述性流行病学方法进行分析。结果 2009-2014年福田区一共报告2036例个案,48h内调查率为100%。报告AEFI中男、女性别比1.30:1,<2岁报告最多占75.69%。AEFI报告数5月最多,2月最少。AEFI总报告发生率为41.46/10万,其中一般反应中以发热、红肿、硬结为主,预防接种异常反应以过敏性皮疹为主。AEFI主要集中在接种后≤1 d。治愈和好转的AEFI占99.95%,死亡1例,为偶合症。结论福田区AEFI监测系统运转正常,所使用疫苗安全,预防接种服务良好,AEFI主要发生在接种当天和<2岁的儿童。
Objective To analyze the incidence of suspected AEFI in Futian District of Shenzhen City from 2009 to 2014 and evaluate the safety of vaccines, the quality of vaccination services and the operation of AEFI monitoring system. Methods The data of 2009-2014 report from China “suspected vaccination anomaly information management system ” were collected and analyzed by descriptive epidemiological method. Results A total of 2036 cases were reported in Futian District from 2009 to 2014, with an investigation rate of 100% within 48 hours. Report male and female AEFI ratio of 1.30: 1, <2 years old report up to 75.69%. The AEFI reports the most in May and the least in February. AEFI total report rate was 41.46 / 100000, of which the general reaction to fever, redness, induration mainly allergic reactions vaccination allergic rash based. AEFI is mainly focused on ≤1 d after inoculation. AEFI cure and improvement accounted for 99.95%, 1 death, for the coupling syndrome. Conclusion The AEFI monitoring system in Futian District was operating normally with good vaccine safety and vaccination services. AEFI occurred mainly on the day of vaccination and in children <2 years of age.