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近年来,有关消化性溃疡(PU)的药物治疗进展很快。本文作一概述。 1.削弱攻击因子: (1)抗酸治疗:抗酸治疗及抑制胃酸分泌依然是PU的重要治疗措施。以往认为抗酸药的治疗作用仅在于中和胃酸,现已证明复方抗酸药胃必治、乐得胃中的镁、铋离子还有促进碳酸氢盐分泌、增强上皮间紧密连接、提高粘膜防御能力的作用。目前,临床多用复方制剂,如胃友、胃得乐、乐得冒、胃必治、胃舒平等,其特点为价格低、副作用小、服用方便,对胃、十二指肠溃疡都有效,系基层及门诊治疗PU的首选药物。 (2)抑制胃酸分泌:①H_2受体拮抗剂:应用最广,约占处方用药的81％。目前常用药有甲氢咪胍、雷尼替丁、法莫替丁、尼刹替丁和罗刹替丁。服药后多数在5～7天内症状改善,2～4周内消失。用法:甲氰咪胍400mg,2次/d;或雷尼
In recent years, medication for peptic ulcer (PU) has progressed rapidly. This article gives an overview. 1. Weakened attack factors: (1) Antacid therapy: Antacid therapy and inhibition of gastric acid secretion is still an important treatment for PU. In the past that the role of antacids in the treatment of acid and only in the stomach, it has been proved that the compound antacids Stomach rule, happy in the stomach of magnesium, bismuth ions also promote bicarbonate secretion, enhance epithelial tight junction, improve mucosal defense The role of ability. At present, the clinical multi-purpose compound preparations, such as stomach friend, Stomach music, happy to take, Stomach must rule, stomach Shuping, etc., characterized by low prices, side effects, easy to take, stomach, duodenal ulcers are effective, Department of grassroots And outpatient treatment of PU’s preferred drug. (2) Inhibition of gastric acid secretion: ① H2 receptor antagonists: the most widely used, accounting for about 81% of prescription medication. At present, there are commonly used drugs megamidine, ranitidine, famotidine, niosartan and loratadine. After taking the majority of symptoms within 5 to 7 days to improve, disappear within 2 to 4 weeks. Usage: Cimetidine 400mg, 2 times / d; or raney