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目的:探讨Survivin和MMP-2在宫颈鳞癌中的表达及其临床意义。方法:对45例宫颈CINⅠ～Ⅱ、18例宫颈CINⅢ和33例宫颈浸润性鳞癌患者分别进行Survivin和MMP-2检查,比较各组患者的阳性表达,并分析其与宫颈病变级别的相关性。结果:Survivin和MMP-2的阳性表达与宫颈病变的级别呈正相关,不同宫颈病变级别的阳性率比较差异均有统计学意义(P<0.05,P<0.01)。结论:临床宫颈病变患者活检后应行Survivin和MMP-2检查,可提示其预后并指导临床治疗。
Objective: To investigate the expression of Survivin and MMP-2 in cervical squamous cell carcinoma and its clinical significance. Methods: Survivin and MMP-2 were examined in 45 cases of cervical CINⅠ-Ⅱ, 18 cases of cervical CINⅢ and 33 cases of invasive cervical squamous cell carcinoma. The positive expression of Survivin and MMP-2 in each group were compared, and their correlations with cervical lesions were analyzed . Results: There was a positive correlation between the positive expression of Survivin and MMP-2 and the grade of cervical lesions. The positive rates of different cervical lesions were statistically significant (P <0.05, P <0.01). Conclusion: Survivin and MMP-2 should be detected after biopsy in patients with clinical cervical lesions, which may indicate the prognosis and guide the clinical treatment.