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目的：定位合成６－Ｏ－丙酰基日本杜鹃素Ⅲ，评价其毒性。方法：以日本杜鹃素Ⅲ为原料合成目标物，用小鼠测定ＬＤ５０。结果：获得目标物并测得ＬＤ＿（５０）＝２．５１ｍｇ／ｋｇ（可信限２．０～３．１９）。结论：日本杜鹃素Ⅲ经６－Ｏ－丙酰化后，毒性降低５倍。
OBJECTIVE: To locate and synthesize 6-O-propionyl Japan rhododoxin III and evaluate its toxicity. Methods: The target substance was synthesized from Japanese Rhododendron III and the LD50 was measured in mice. RESULTS: The target was obtained and measured for LD 50 = 2.51 mg/kg (credential 2.0 - 3.19). Conclusion: The toxicity of Japanese rhododoxin III is reduced by 5 times after 6-O-propionylation.