目的：对 Ｃ Ｂ Ｎ 进行药代动力学研究，并与毒性累积法进行比较。方法：采用荧光分光光度 法测定小鼠血浆中 Ｃ Ｂ Ｎ 的含量，采用 Ｈ Ｐ Ｌ Ｃ 法测定兔血浆中 Ｃ Ｂ Ｎ 的主要成分葛根素（ Ｐ Ｕ） 和人参皂甙 Ｒｇ１（ Ｇ Ｒｇ１） ，计算药代动力学参数；以动物急性死亡率法估算（ Ｃ Ｂ Ｎ） 动力 学参数。结果： Ｃ Ｂ Ｎ 及其中 主要成 分 Ｐ Ｕ 和 Ｇ Ｒｇ１ 均符合一级动力学代谢，二室模型分布。结论：以有效成分的药代动力学法研究复方 Ｃ Ｂ Ｎ 能更好 地评价其 药代动力学过程。 Objective: To study the pharmacokinetics of CBN and compare it with the toxicity accumulation method. METHODS: The content of C B N in plasma of mice was determined by fluorescence spectrophotometry. Puerarin (P U) and ginsenoside Rg1 (GRg1), the main components of C B N in rabbit plasma, were determined by H P L C method. Pharmacokinetic parameters were calculated; (C B N) kinetic parameters were estimated using the animal acute mortality method. Results: C B N and its main components P U and GRg1 all met the first-order kinetics metabolism, and the two-compartment model was distributed. Conclusion: The pharmacokinetic study of the active ingredient in compound C B N can better evaluate its pharmacokinetics process.